Resumo Objetivos: avaliar mudanças no uso de substâncias psicoativas (SPA) durante a gravidez. Métodos: estudo longitudinal, com gestantes usuárias de SPA em seguimento pré-natal. Resultados: 76 gestantes, que utilizavam: tabaco (84,2%, n=64), álcool (73,7%, n=56), cocaína (27,6%, n=21), maconha (26,3%, n=20) e crack (13,1%, n=10). Houve interrupção espontânea em 60% (n=6) das usuárias de crack, 57,1% (n=12) de cocaína e 50% (n=28) de álcool. Após Intervenção Breve, cessaram o consumo 78,9% (15 do total de 19) das usuárias de álcool e 70% (7 do total de 10) de maconha, e as tabagistas diminuíram o número de cigarros. Conclusões: a redução do consumo de SPA espontânea e após intervenções reforçam a gravidez como janela de oportunidade para abordagem do uso de drogas.

Abstract Objectives: evaluate changes in the use of psychoactive substances (PAS) throughout pregnancy. Methods: longitudinal study, with pregnant women users of PAS at a prenatal follow-up. Results: 76 pregnant women used: tobacco (84.2%, n=64), alcohol (73.7%, n=56), cocaine (27.6%, n=21), marijuana (26.3%, n=20) and crack (13.1%, n=10). Spontaneous interruption had occurred in 60% (n=6) of crack users, 57.1% (n=12) of cocaine and 50% (n=28) of alcohol. After the Brief Intervention, 78.9% (15 of the total of 19) of alcohol users and 70% (7 of the total of 10) of marijuana users discontinued the consumption and there was a reduction in smoking cigarettes. Conclusions: the spontaneous reduction in the consumption of PAS and after the interventions, pregnancy is a window of opportunity to reduce the use of drugs.

Colonization by Group B Streptococcus (GBS) is highly prevalent among pregnant women, with prevalence rates ranging between 4% and 30%. The infection may be transmitted vertically and may result in serious neonatal consequences. In the period from November 2003 to May 2004, a cross-sectional study was carried out among 316 parturients at the Jundiaí Teaching Hospital to establish the prevalence of genital GBS colonization, to identify the factors associated with colonization and the characteristic phenotypes of these streptococci. Samples from rectal and vaginal areas were collected for selective culture in Todd-Hewitt broth. Susceptibility to 7 antimicrobial agents was tested using the antibiotic diffusion disk technique, and the isolated strains were classified using specific antisera. The prevalence of GBS colonization was 14.6%. No strain was resistant to penicillin, ampicillin, erythromycin or nitrofurantoin. The majority of strains were sensitive to cephalothin. Greatest resistance was to gentamicin (76.1%), followed by clindamycin (17.4%). The most frequent serotype was Ib (23.9%), followed by serotypes II and Ia (19.6% and 17.4%, respectively). There was no correlation between serotype and greater antimicrobial resistance. In conclusion, the prevalence of GBS in parturients was high and penicillin continues to be the drug of choice for intrapartum prophylaxis. The most frequent serotype (Ib) found in this study differs from those found in the majority of studies carried out in other countries, revealing the need to identify prevalent serotypes in each region so that specific vaccines can be designed.